Review of issues of premature rupture of membranes.Review article.Institute for the Care of Mother and Child, Prague, Czech Republic, Department of Gynaecology and Obstetrics, Institute for Postgraduate Medical Education, Prague, Czech Republic, Department of Gynaecology and Obstetrics, Charles University Hospital, Pilsen, Czech Republic.Critical review of available information on issues of premature rupture of membranes with special attention to recommended procedures.Incidence of premature rupture of membranes varies from 4.5% to 14% and in about 30% of cases it is a cause of preterm delivery, and therefore it contributes substantially to perinatal and infant mortality and morbidity. To minimize this effect, recommended procedures are stipulated. Different types of clinical situations are evaluated and specific measures listed to provide practical guidelines based on available information.Premature rupture of membranes is an important topic in perinatology and proper management can affect pregnancy outcome. This article provides up-to-date recommended procedures in particular situation during pregnancy with focus on practical measures.