Gammadelta T cells: functional plasticity and heterogeneity.
Copyright policy )Gammadelta T cells: functional plasticity and heterogeneity.
Gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their biological function(s) remains unclear. On the basis of studies of gammadelta T cells in infectious and autoimmune diseases, we argue that gammadelta T cells perform different functions according to their tissue distribution, antigen-receptor structure and local microenvironment; we also discuss how and at what stage of the immune response they become activated.
- University of Leeds United Kingdom
- University of East Anglia United Kingdom
570, T-Lymphocytes, 610, Receptors, Antigen, T-Cell, gamma-delta, Infections, Autoantigens, Autoimmune Diseases, Disease Models, Animal, Genes, T-Cell Receptor, Mice, Animals, Humans, Cell Lineage, Immunologic Surveillance
570, T-Lymphocytes, 610, Receptors, Antigen, T-Cell, gamma-delta, Infections, Autoantigens, Autoimmune Diseases, Disease Models, Animal, Genes, T-Cell Receptor, Mice, Animals, Humans, Cell Lineage, Immunologic Surveillance
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).753 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!