Malignant neoplasms of maxillary sinuses are a serious diagnostic and therapeutic challenge, so the objective of a clinician is the planning of a cost-effective strategy promptly leading to proper diagnosis and the onset of treatment. Thus the aim of the paper was the elaboration of diagnostic strategy in maxillary neoplasms. There were analyzed 163 case records of 78 patients with maxillofacial neoplasms. The number and sequence of the conventional radiograms as well as diagnostic imaging methods were registered. There was proposed an algorithm of application of imaging techniques in diagnostics of neoplasms of maxillary antra. It was found that conventional X-rays are still valuable in screening for sinus pathology and as indication of the necessity of performing other imaging examinations. Computed tomography and magnetic resonance are complementary in visualization of pathologic masses and bone tissue destruction.