
Diclofenac is a potent anti-inflammatory and analgesic compound with good antipyretic and uricosuric properties. It is one of the most potent inhibitors of prostaglandin synthetase known. It shows a favourable therapeutic ratio considering its efficacy, and proved superior to the reference drugs in terms of gastro-intestinal tolerability. All metabolites are clearly less potent than the parent compound.
Analgesics, Diclofenac, Dose-Response Relationship, Drug, Anti-Inflammatory Agents, Non-Steroidal, Anti-Inflammatory Agents, Drug Tolerance, Uricosuric Agents, Arthritis, Experimental, Models, Biological, Rats, Mice, Animals, Humans, Cyclooxygenase Inhibitors, Phenylacetates
Analgesics, Diclofenac, Dose-Response Relationship, Drug, Anti-Inflammatory Agents, Non-Steroidal, Anti-Inflammatory Agents, Drug Tolerance, Uricosuric Agents, Arthritis, Experimental, Models, Biological, Rats, Mice, Animals, Humans, Cyclooxygenase Inhibitors, Phenylacetates
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