[Rituximab, a chimeric mouse-human anti-CD20 monoclonal antibody].
Copyright policy )[Rituximab, a chimeric mouse-human anti-CD20 monoclonal antibody].
CD20 antigen is expressed on nearly all human B-cells and B-lymphoma cells. Rituximab is a chimeric anti-CD20 monoclonal antibody with mouse variable and human constant regions. The toxicities of rituximab are mainly infusion-related, non-hematological grade 1 or 2 episodes. Of the 11 eligible patients enrolled in the phase I study in Japan, 2 showed CR and 5 showed PR. 90 relapsed pts were enrolled in the subsequent phase II study and treated with rituximab at 375 mg/m2 x 4 weekly infusions. The overall response rates in relapsed indolent B-cell lymphoma and mantle cell lymphoma were 61%(37/61) and 46%(6/13), respectively. Rituximab is a novel, effective anti-lymphoma agent with acceptable toxicities.
- National Cancer Center Hospital Korea (Republic of)
Lymphoma, B-Cell, Clinical Trials, Phase I as Topic, Recombinant Fusion Proteins, Antibodies, Monoclonal, Antineoplastic Agents, Radioimmunotherapy, Antigens, CD20, United States, Antibodies, Monoclonal, Murine-Derived, Mice, Clinical Trials, Phase II as Topic, Treatment Outcome, Japan, Doxorubicin, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, Prednisone, Rituximab, Cyclophosphamide
Lymphoma, B-Cell, Clinical Trials, Phase I as Topic, Recombinant Fusion Proteins, Antibodies, Monoclonal, Antineoplastic Agents, Radioimmunotherapy, Antigens, CD20, United States, Antibodies, Monoclonal, Murine-Derived, Mice, Clinical Trials, Phase II as Topic, Treatment Outcome, Japan, Doxorubicin, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, Prednisone, Rituximab, Cyclophosphamide
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