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Chinese Journal of Traumatology
Article . 2002
Data sources: Europe PubMed Central
Claim

Blocking transforming growth factor-beta receptor signaling down-regulates transforming growth factor-beta1 autoproduction in keloid fibroblasts.

descriptionPublicationkeyboard_double_arrow_right Article 14 May 2002 English Journal:Chinese journal of traumatology = Zhonghua chuang shang za zhi, volume 5 (issn: 1008-1275, Copyright policy )
Authors: Wei, Liu; Zehao, Cai; Danru, Wang; Xiaoli, Wu; Lei, Cui; Qingxin, Shang; Yunliang, Qian; +1 Authors

pmid: 11904067

Blocking transforming growth factor-beta receptor signaling down-regulates transforming growth factor-beta1 autoproduction in keloid fibroblasts.

Abstract

To study transforming growth factor-beta1 (TGF-beta1) autoproduction in keloid fibroblasts and the regulation effect of blocking TGF-beta intracellular signaling on rhTGF-beta1 autoproduction.Keloid fibroblasts cultured in vitro were treated with either rhTGF-beta1 (5 ng/ml) or recombinant adenovirus containing a truncated type II TGF-beta receptor gene (50 pfu/cell). Their effects of regulating gene expression of TGF-beta1 and its receptor I and II were observed with Northern blot.rhTGF-beta1 up-regulated the gene expression of TGF-beta1 and receptor I, but not receptor II. Over-expression of the truncated receptor II down-regulated the gene expression of TGF-beta1 and its receptor I, but not receptor II.TGF-beta1 autoproduction was observed in keloid fibroblasts. Over-expression of the truncated TGFbeta receptor II decreased TGF-beta1 autoproduction via blocking TGF-beta receptor signaling.

Related Organizations
Keywords

Receptor, Transforming Growth Factor-beta Type I, Down-Regulation, Gene Expression, Fibroblasts, Protein Serine-Threonine Kinases, Sensitivity and Specificity, Up-Regulation, Keloid, Trans-Activators, Humans, RNA, Messenger, Activin Receptors, Type I, Receptors, Transforming Growth Factor beta, Cells, Cultured, Signal Transduction

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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