[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].

N A, Malygina; I V, Kostomarova; G V, Deriagin; L D, Serova

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Article . 2002

Data sources: Europe PubMed Central

[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].

descriptionPublicationkeyboard_double_arrow_right Article 05 Jun 2002 Russian Journal:Terapevticheskii arkhiv, volume 74 (issn: 0040-3660,

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Authors: N A, Malygina; I V, Kostomarova; G V, Deriagin; L D, Serova;

pmid: 11899831

[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].

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Abstract

To determine incidence of HindIII alleles of lipoprotein lipase (LPL) in Russian elderly patients with stable effort angina (SEA) functional class II-III regarding lipid metabolism.Genotyping by LPL gene was performed in 103 patients with SEA. Of them 13 patients survived myocardial infarction (MI), 29 patients had diabetes mellitus.Incidence of alleles of HindIII DNA-polymorphism of LPL gene both in healthy and IHD patients is comparable with that in the West European populations.Genotype H+H+ of LPL gene is one of the markers of predisposition to MI, while allele H- is one of the resistance marks.

Keywords

Adult, Aged, 80 and over, Electrophoresis, Agar Gel, Male, Polymorphism, Genetic, Genotype, Myocardial Infarction, Myocardial Ischemia, DNA, Deoxyribonuclease HindIII, Middle Aged, Polymerase Chain Reaction, Lipoprotein Lipase, Diabetes Mellitus, Type 1, Humans, Female, Angina, Unstable, Aged

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