Transradial arterial access is an alternative approach for coronary interventions. The utilization of these cardiac systems may facilitate endovascular treatment of other vascular territories. This report describes our first experience with percutaneous transluminal renal artery angioplasty and stenting (PTRAS) using the transradial approach. This case demonstrates the feasibility of the radial approach to treat severe renal artery disease safely with PTRAS. Comparison with femoral and brachial arterial access sites is beyond the scope of this paper, but the cardiac literature has demonstrated the safety and efficacy of transradial artery access. With refinement of the endovascular equipment, the radial approach could become an attractive alternative entry site for renal artery interventions.