[Association of nm23-H1 with orthopedic oncological conditions].
Copyright policy )[Association of nm23-H1 with orthopedic oncological conditions].
To explore the correlation between nm23-H1 gene and malignant and semi-malignant bone tumors.Thirty surgical specimens were collected, including 8 osteosarcomas, 7 giant cell tumors, 4 chondrosarcomas, 2 Ewing's sarcomas, 2 malignant fibrohistocytomas, 1 neurofibrosarcoma, 1 schwannoma, and 5 metastatic cancers. The expression of nm23-H1 in these specimens was observed by in situ hybridization and immunohistochemical staining.The expression of nm23-H1 in 4 cases of primary giant cell tumor (GCT) was high, but was low or absent in 3 recurrent ones. In 4 cases of chondrosarcomas, the expression was positive. Its expression was basically negative in Ewing's tumor, malignant fibrous histiocytoma and metastatic sarcomas.There is no association of nm23-H1 with osteosarcoma.
- First Hospital of Shijiazhuang China (People's Republic of)
Adult, Male, Bone Neoplasms, NM23 Nucleoside Diphosphate Kinases, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Antigens, Neoplasm, Nucleoside-Diphosphate Kinase, Humans, Female, RNA, Messenger, In Situ Hybridization, Monomeric GTP-Binding Proteins, Transcription Factors
Adult, Male, Bone Neoplasms, NM23 Nucleoside Diphosphate Kinases, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Antigens, Neoplasm, Nucleoside-Diphosphate Kinase, Humans, Female, RNA, Messenger, In Situ Hybridization, Monomeric GTP-Binding Proteins, Transcription Factors
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