It intended to investigate different craniofacial types of anterior open bite.116 patients with anterior open bite were selected randomly. The craniofacial morphology and airway structures were measured and analyzed with multivariate analyses.4 factors (mandible rotation factor, facial height factor, dental and skeletal saggittal factor and maxillary rotation factor) were extracted from 156 items including age, gender and craniofacial characteristics by data reduction and factor analysis procedure. Anterior open-bite patients were classified into 5 types, which are dental-alveolar type, mandibular clockwise rotation type, long face type, maxillary counter-clockwise rotation type and skeletal Class III type with K-means cluster analysis procedure. A simple cluster method was summarized to facilitate clinical practice.It suggested that classification play an important role in diagnosis and decision making procedure.