[X-linked thin basement membrane nephropathy was linked with COL4A5 gene].

To genetically analyze 9 thin basement membrane nephropathy (TBMN) pedegrees using microsatellite marker 2B6 and DXS101 closely linked with COL4A5 gene located on chromosome X.Genomic DNA was extracted. Highly polymorphic microsatellite markers (2B6 and DXS101) closely linked with COL4A5 gene located on chromosome X were amplified with PCR. Nine TBMN families were analysed.Three of 9 TBMN families were linked with COL4A5 gene on chromosome X (lod score = 2.7, theta = 0.00).X-linked TBMN is linked with COL4A5 gene on chromosome X.

Related Organizations

Beijing Hospital
China (People's Republic of)
Beijing Chao-Yang Hospital
China (People's Republic of)

Keywords

Adult, Collagen Type IV, Family Health, Male, X Chromosome, Genotype, Genetic Linkage, Nephritis, Hereditary, DNA, Middle Aged, Polymerase Chain Reaction, Basement Membrane, Pedigree, Gene Frequency, Humans, Female

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