
2-Pyridyl-thioacetamide (2-PTA) was synthesized at IDR in 1968. This molecule showed strong antiulcer/antisecretory effects in animals and man by inhibiting the proton pump. Based on our work Astra developed omeprazole which is the No. 1 drug in the world from 1996. 2-PTA remained a very popular template for drug design for a quarter of century.
Hungary, Peptic Ulcer, Research, Academies and Institutes, Humans, Anti-Ulcer Agents
Hungary, Peptic Ulcer, Research, Academies and Institutes, Humans, Anti-Ulcer Agents
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