[Interleukin-1beta and depressive states].
Copyright policy )[Interleukin-1beta and depressive states].
Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite effects of two doses of IL-1 beta were observed also in a test with saccharine.
- Institute of Experimental Medicine Russian Federation
- Russian Academy of Sciences Russian Federation
Male, Dose-Response Relationship, Drug, Depression, Pyrogens, Motor Activity, Rats, Exploratory Behavior, Animals, Rats, Wistar, Maze Learning, Social Behavior, Interleukin-1
Male, Dose-Response Relationship, Drug, Depression, Pyrogens, Motor Activity, Rats, Exploratory Behavior, Animals, Rats, Wistar, Maze Learning, Social Behavior, Interleukin-1
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