JTV-519 Japan Tobacco.
Copyright policy )JTV-519 Japan Tobacco.
Japan Tobacco is developing the mixed action ion channel blocker, JTV-519, which has potential use as an antiarrhythmic. The drug is a novel cardioprotectant derivative of 1,4-benzothiazepine for which phase I trials were completed in the third quarter of 1998; phase II trials started in the fourth quarter of 1998 for the potential treatment of myocardial infarction. Studies have shown that JTV-519 has a strong cardioprotective effect against catecholamine-induced myocardial injury and against ischemia/reperfusion injury. In experimental myofibrillar overcontraction models, it demonstrated greater cardioprotectant effects than propranolol, verapamil and diltiazem.
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- University of Hong Kong China (People's Republic of)
- Queen Mary Hospital China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
- Hospital Authority China (People's Republic of)
Cardiotonic Agents, Anti-Arrhythmia Agents - metabolism - pharmacology, Thiazepines, Myocardial Reperfusion Injury, Thiazepines - metabolism - pharmacology, Ion Channels, Membrane Potentials, Animals, Cardiotonic Agents - metabolism - pharmacology, Membrane Potentials - drug effects, Annexin A5, Protein Kinase C, Protein Kinase C - metabolism - physiology, Myocardial Stunning, Annexin A5 - metabolism - physiology, Myocardial Reperfusion Injury - drug therapy, Cell Death, Myocardium, Calcium - metabolism, Myocardium - pathology, Cell Death - drug effects, Myocardial Stunning - drug therapy, Calcium, Ion Channels - antagonists & inhibitors, Anti-Arrhythmia Agents
Cardiotonic Agents, Anti-Arrhythmia Agents - metabolism - pharmacology, Thiazepines, Myocardial Reperfusion Injury, Thiazepines - metabolism - pharmacology, Ion Channels, Membrane Potentials, Animals, Cardiotonic Agents - metabolism - pharmacology, Membrane Potentials - drug effects, Annexin A5, Protein Kinase C, Protein Kinase C - metabolism - physiology, Myocardial Stunning, Annexin A5 - metabolism - physiology, Myocardial Reperfusion Injury - drug therapy, Cell Death, Myocardium, Calcium - metabolism, Myocardium - pathology, Cell Death - drug effects, Myocardial Stunning - drug therapy, Calcium, Ion Channels - antagonists & inhibitors, Anti-Arrhythmia Agents
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