One of the most important prerequisities concerning the process of selecting drugs for rational pharmacotherapy is the availability of independent information about them. The first self-existent Drug Information Center (DIC) in Slovakia was established in May 1997 at the Department of Pharmacology, School of Medicine, Comenius University in Bratislava. The organization of DIC and its activities are similar to other analogous centers in other countries. DIC provides free drugs information to all medical professionals. The majority of inquiries are from hospital physicians followed by general practitioners and staff of the University. The most frequent questions involve basic information about drugs, pharmacotherapy during pregnancy and lactation, adverse drug reactions, registration of new drugs, drug action etc.