Addison's disease is due to an insufficiency of corticosuprarrenal hormones to maintain the peripheral needs and its clinical sign is a constitutional syndrome with cutaneous hyperpigmentation and low blood pre-assure. The ethiology has drastically variated in the last century; being the origin almost exclusively tuberculous at the beginning of 1900 and mainly autoimmune actually. Nowadays it is difficult to understand Addison's disease out of the context of autoimmune polyglandular syndromes in view of the frequent association to other endocrinopathies. The present article pretend to realize a vision of the global disease related to these multiple endocrine deficits.