
Orofacial clefts are congenital structural deficits involving the lip with or without the palate. The genetic origins of orofacial clefts have been considered as heterogeneous for a long time. Non-syndromatic clefts are based on complex traits.The different approaches towards the genetics of this multifactorial disease are discussed and the consequences for genetic counselling for patients, persons at risk and their relatives are reflected upon.
Adult, Cleft Palate, Male, Cleft Lip, Chromosome Mapping, Humans, Female, Genetic Predisposition to Disease, Syndrome, Child, Pedigree
Adult, Cleft Palate, Male, Cleft Lip, Chromosome Mapping, Humans, Female, Genetic Predisposition to Disease, Syndrome, Child, Pedigree
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