Young and middle-aged males with lower education levels, unemployed, poor and laborers are most susceptible to progressive pulmonary tuberculosis. The most severe forms of the disease are more common in single persons. The factors that promote its progression are as follows: poor living conditions, migration, chronic alcoholism, which shows these population groups to be at risk for poor prognosis forms. The disease is detected mainly on patients' referral. Pulmonary lesions were primarily bilateral and frequently primary. They are characterized by acute onset, marked intoxication, cathexis, excessive rale, scanty sputum, anemia, lymphopenia, drastically accelerated erythrocyte sedimentation rate. Sputum Mycobacteria tuberculosis are occasionally found. The outcomes of acute progressive tuberculosis are chiefly poor, which requires that effective methods of treatment and prevention should be developed for risk groups.