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Farelerde korunga bitkisinin (Onobrychis viciifolia) bağırsaklara etkisi

Authors: Ince, Sinan; Filazi, Ayhan;

Farelerde korunga bitkisinin (Onobrychis viciifolia) bağırsaklara etkisi

Abstract

Bu araştırmada, korunga bitkisi (Onobrychis viciifolia) ekstraktının Wistar albino soyu en az iki aylık fare jejunum ve ileumu üzerindeki etkilerinin izole organ banyosunda in vitro testlerle ortaya konması amaçlanmıştır. Jejunum ve ileum dokusunda, asetilkolin EC50, betanekol EC50, atropin (10-8-10-7 M) ve korunga ekstraktı 0.1-6.4 mg/ml derişimlerde uygulanarak tek başlarına ve bir arada doku üzerindeki etkileri incelendi. Ayrıca histamin ve nikotinin jejunum ve ileum üzerindeki etkileri incelendi. Ekstraktın (6.4 mg/ml) fare jejunum ve ileum düz kası üzerinde gevşetici etki yaptığı, asetilkolin EC50 ve betanekol EC50’nin ekstrakt (3.2 ve 6.4 mg/ml) varlığında kastırıcı etkilerinin, atropin varlığında ekstraktın (6.4 mg/ml) gevşetici etkisinin azaldığı ve böylece bitkinin antimuskarinik ajan olarak rol oynadığı belirlendi. Bitki ekstraktının bağırsaklar üzerindeki etkilerini reseptörler düzeyinde oluşturduğu, bu etkinin görülmesinde içeriğinde bulunan etkin maddelerin özellikle de flavonoidlerin rol oynadığı sonucuna varılmıştır.

Country
Turkey
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Keywords

yem bitkileri, Flavonoidler, bitki özütü, Gastroenteroloji ve Hepatoloji, ileum, bağırsaklar, fareler, ince bağırsak, Veterinerlik, korunga, Biyoloji, Onobrychis viciifolia

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green