A case of epidermolysis bullosa acquisita (EBA) occurring in a 30 year-old-farmer is described. Diagnosis was suggested by clinical signs (adult-onset of mechano-bullous lesions healing with atrophic scar and milia formation, in absence of family history, photosensitivity and urine darkening); it was confirmed by laboratory data (normal urinary porphyrins excretion) and histology findings (dermo-epidermal splitting on light microscopy, junctional deposits of IgG and C3 on immunomicroscopy, ultrastructural detection and amorphous granular material below the lamina densa). Among the immune bullous disorders with IgG and C3 deposition, EBA has the deepest location of pathogenic events.