This article deals with cases of overlap between indirect interrogative clauses and relative clauses in Latin. After overviewing the status quaestionis, attention is paid to factors involved in creating ambiguity, such as the semantic class of governing verbs, the type of indirect interrogative clauses and relative clauses that can overlap, the role of pronoun homophony, the selection of verb mood, and its significance in terms of information structure. Particular regard is paid to Classical Latin.