Tourism activity is characterized by transversality that involves multiple sectors. In the planning of tourist development, in fact, the aspects relating to mobility, services, management of resources and attractive elements, promotion, territorial policies, urban redevelopment interventions are involved. The Covid-19 pandemic, from which we seem to be emerging with difficulty, retrieved attention on the need to identify new ways of using and enjoying territories that have to be more compatible with the needs of sustainability (economic, social, environmental) and preservation of natural areas. These areas are essential for the health and the equilibrium of the earth, at the same time they are a precious heritage of resources-opportunities for the development of sustainable practices of fruition. In protected natural areas, the territorial development is strongly connected also to tourist use but this development requires respect both for the needs of the resident population and for the territorial vocational characteristics. In the framework of these considerations, this study proposes a first definition of the territorial propensity for transformation, also from a tourist point of view, of the Partenio Regional Park intended as a territorial holistic system. By the design of thematic maps about transformability, elaborated in GIS, the system of the Partenio Regional Park can be articulated according to its level of propensity to territorial transformation. Territorial mapping as first result of analysis can represent a useful tool for supporting decision-makers in the definition of a global system design for sustainable tourism development of Partenio’s Park.