Landslides are one of the most commonly observed territorial effects after a strong-motion seismic event. Although landslides are considered a secondary hazard to human lives, as compared with the safety of the buildings, they can cause significant damage to infrastructure networks that determine problems in the immediate post-earthquake during the emergency and reconstruction phases. Therefore it is important to calibrate reliable procedures for regional-scale assessment of seismic landslide susceptibility and hazard. The tools available for assessing regionalscale stability of slopes are empirically related to the earthquake intensity, yet they often provide poor useful information for practical purposes. The technical literature proposes several methods that allow for estimating slope performance under dynamic conditions or are able to evaluate effectively the parameters required for the procedures most commonly used in practice. This note briefly outlines the criteria for extending to the regional scale the procedures proposed by Tropeano et al. (2017) for assessing the site-specific performance of slopes during a strong-motion earthquake. A preliminary application is also shown for the main events of 2016 seismic sequence in Central Italy.