This chapter aims to propose a conceptual model of knowledge management for cultural heritage, with a focus on craftsmanship. A review of the different models developed by scholars, especially those concerning knowledge retrieval and reuse, and an analysis of the main features and peculiarities of the crafts activities allows for the identification of potential links between knowledge management models and crafts knowledge. The conceptual clarification and empirical illustration of the proposed model in a specific context of analysis - the Borgo Orefici pilot area in the historic centre of Naples - led to the identification of some indicators for the variables presented in the model.