Transposition is an exchange of the position of two adjacent teeth, which can be incomplete or complete. The aim of this case report was to illustrate the non-extraction treatment of transposition between maxillary canine and first premolar using multibrackets fixed appliance. The treatment of this anomaly varies from acceptance to correction and should consider several aspects such as age, dental morphology, malocclusion, facial esthetics, stage of root development, the position of the root apices, and magnitude of the transposition. The patient, a boy, aged 11 years, had a class III malocclusion with narrow maxillary arch, crossbite from 1.2 to 1.5 and 2.2, with transposition of 2.3. The early diagnosis plays a significant role in considering esthetics and functional factors in deciding which treatment strategy should be followed to promote the patient’s self-esteem. The key to a successful and stable result is precise treatment planning and careful orthodontic management.