In recent years, research conducted in the US and in Italy has demonstrated production of radioisotopes in Plasma Focus (PF) devices, and particularly, on what could be termed “endogenous” production, to wit, production within the plasma itself, as opposed to irradiation of targets. This technique relies on the formation of localized small plasma zones characterized by very high densities and fairly high temperatures. The conditions prevailing in these zones lead to high nuclear reaction rates, as pointed out in previous work by several authors [1,2,3,4]. Further investigation of the cross sections involved has proven necessary to model the phenomena involved. In this paper, the present status of research in this field is reviewed, both with regards to cross section models and to experimental production of radioisotopes. Possible outcomes and further development are discussed.