The concept of “vacuum” has always been of interest to physics, which over time has tried to define it by giving it a physical-mathematical meaning. From Descartes' “dense vacuum” — substance space that can take on a positive form, even if materially less evident — to the definition of a “non-empty vacuum state” in the latest quantum theories, due to the presence of quantum vacuum fluctuations. The latest results of frontier research show how the concept of a vacuum, as a space devoid of physical and dynamic properties and passive theatre of natural phenomena, is no longer sustainable. For physicists, there is no vacuum: emptiness and nothingness are represented by the quantum field, in which everything is generated and destroyed.