A case of ovarian carcinoma, never previously reported in bear is described. A 37-year-old, nulliparous, female Eurasian brown bear hosted at the Falconara Parco Zoo in Italy, showed neurological clinical signs including bilateral blindness and signs of hemiparesis involving both limbs of the left side. A therapy based on fluid, dexamethasone sodium phosphate, ranitidine, ceftriaxone, propentofylline, and a vitamin B complex administration was started after the onset of sintomatology. After about a week of therapy the bear was able to stand up and walk, partially recovered the vision and ate regularly. Despite this initial improvement, three weeks after the clinical onset the bear died. At necropsy a large mass involving the left ovary and brain metastases has been found. Based on the typical histological and immunohistochemical features of neoplastic cells, this tumor was diagnosed as papillary to solid serous type ovarian carcinoma. Because of the scattered distribution pattern of neoplastic nodules, the involvement of the brain and lombo-aortic lymph node was considered to be metastatic. Only few reports of neoplasms in Ursidae can be found in scientific literature and these include lymphosarcoma, osteoma, osteosarcomas, chondrosarcoma, squamous cell, biliary, thyroid, mammary, and hepatocellular carcinomas. According to these results, the presence of tumor should be considered in bears with neurological signs.