The manuscript deals with personalized medicine and medical liability in Europe and Italy, addressing the importance of synergistic collaboration between clinical and medico-legal professionals in order to appropriately investigate medical errors and prevent any future adverse event. Following a rapid epidemiological overview of mala praxis in Europe, the manuscript presents and discusses the International Guidelines developed and adopted by the International Academy of Legal Medicine (IALM), which guide the work of the medical experts under both criminal and/or civil law. Finally, the manuscript proposes the indispensability of a quality assurance and accreditation system for clinical and medico-legal reports along with a shared and integrated methodology for managing health claims in order to prevent adverse events. © PI-ME, Pavia 2017.