We depict the relative sea-level rise scenarios for the year 2100 from four areas of the Italian peninsula. Our estimates are based on the Rahmstorf (2007) and IPCC-AR5 reports 2013 for the RCP-8.5 scenarios (www.ipcc.ch) of climate change, adjusted for the rates of vertical land movements (isostasy and tectonics). These latter are inferred from the elevation of MIS 5.5 deposits and from late Holocene sea-level indicators, matched against sea-level predictions for the same periods using the glacio-hydro-isostatic model of Lambeck et al. (2011). We focus on a variety of tectonic settings: the subsiding North Adriatic coast (including the Venice lagoon), two tectonically stable Sardinia coastal plains (Oristano and Cagliari), and the slightly uplifting Taranto coastal plain, in Apulia. Maps of flooding scenarios are shown on high-resolution Digital Terrain Models mostly based on Lidar data. The expected relative sea-level rise by 2100 will change dramatically the present-day morphology, potentially flooding up to about 5500 km2 of coastal plains at elevations close to present-day sea level. The subsequent loss of land will impact the environment and local infrastructures, suggesting land planners and decision makers to take into account these scenarios for a cognizant coastal management. Our method developed for the Italian coast can be applied worldwide in other coastal areas expected to be affected by marine ingression due to global climate change.