Since the Goldratt and Cox’s (1984) seminal study, Theory of Constrains has evolved from a simple production scheduling software into a management philosophy, with practices and principles spanning a multitude of operation management disciplines. A variety of studies has investigated how production control is carried out in a Theory of Constrains environment, but most of research available lacks in providing an overall vision of this issue. In order to contribute to this gap, using theoretical investigation and the empirical study of five case studies, this article compares the characteristics of TOC with those typical of three shop floor control systems, i.e. MRP, JIT and Daily Rate. As result, the research identifies an interpretative framework based on the distinguishing characteristics of Theory of Constrains. The framework supports the analysis of the nature and scope of these four systems by highlighting the main differences between them.