Negative experiences in human development can settle symptoms of disease or life span disorder. Developmental trauma is a hidden pandemic leading to a multi-layered array of negative outcomes across the lifespan, including critical health conditions and increased healthcare utilization. Such a scenario represents a major socio-economic burden with costs for health and social care and for society as a whole. A trauma-informed public health approach puts childhood adversities at the core of treatment and service provision. It becomes important to outline how a trauma-informed public health approach embedding the recognition of the Developmental Trauma Disorder diagnosis represents a major shift to conceptualizing health and social care provision and to recognizing the pervasiveness of adverse experiences. A projective cost analysis is elaborated to illustrate how the societal, health and social care costs would be reduced if trauma-related policies were implemented. A multidisciplinary view – which includes an economic case aspect – could strengthen ACEs prevention efforts: it could raise awareness of this issue, and adopt useful health and social policies in an integrated perspective.