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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio della ricer...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Archivio della ricerca- Università di Roma La Sapienza
Doctoral thesis . 2016
Data sources: Archivio della ricerca- Università di Roma La Sapienza
Claim

Valutazione dell’associazione tra velocità di degradazione del 5-FU, TSER, MTHFR, DPYD e tossicità in pazienti affetti da neoplasia del colon-retto in trattamento chemioterapico con fluoropirimidine

descriptionPublicationkeyboard_double_arrow_right Doctoral thesis 22 Dec 2016 Italy Italian
Authors: MARCHETTI, LUCA;

handle: 11573/924495

Valutazione dell’associazione tra velocità di degradazione del 5-FU, TSER, MTHFR, DPYD e tossicità in pazienti affetti da neoplasia del colon-retto in trattamento chemioterapico con fluoropirimidine

Abstract

Le varianti genetiche sono responsabili di circa il 10-40% degli eventi, dal severo al grave, correlati alla tossicità con fluoropirimidine22. Scopo dello studio è stato quello di indagare l’associazione tra polimorfismi genici (MTHFR, DPYD e TSER) , velocità di degradazione del 5-FU (5FU-DR) e tossicità da trattamenti chemioterapici a base di 5-FU in pazienti con diagnosi di neoplasia del colon-retto. Obiettivo secondario dello studio è valutare il ruolo della 5FUDR come fattore predittivo di risposta al trattamento a base di 5FU.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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