Reliability and availability of sensing information gathered from local spectrum sensing (LSS) by a single Cognitive Radio is strongly affected by the propagation conditions, period of sensing, and geographical position of the device. For this reason, cooperative spectrum sensing (CSS) was largely proposed in order to improve LSS performance by using cooperation between Secondary Users (SUs). The goal of this chapter is to provide a general analysis on CSS for cognitive radio networks (CRNs). Firstly, the theoretical system model for centralized CSS is introduced, together with a preliminary discussion on several fusion rules and operative modes. Moreover, three main aspects of CSS that substantially differentiate the theoretical model from realistic application scenarios are analyzed: (i) the presence of spatiotemporal correlation between decisions by different SUs; (ii) the possible mobility of SUs; and (iii) the nonideality of the control channel between the SUs and the Fusion Center (FC). For each aspect, a possible practical solution for network organization is presented, showing that, in particular for the first two aspects, cluster-based CSS, in which sensing SUs are properly chosen, could mitigate the impact of such realistic assumptions.