In recent years drones have become an innovative and powerful tool for the documentation of archaeological sites and for the identification of buried remains. In this study, firstly, the Greek-Etruscan sanctuary of Gravisca (Tarquinia, Italy) was documented using drone aerial photogrammetry. Secondly, it has been possible to accurately identify around the site the marks of buried structures analysing the health status of vegetation through the multispectral remote sensing and applying vegetation indexes. The identified marks may allow to hypothesize the presence of an Isis sanctuary in Gravisca, already attested by epigraphic sources.