Shiitake mushrooms (Lentinula edodes are a worldwide known type of mushroom, employed in the traditional Asiatic medicine for healthy effects, such as immune modulation, reduction of blood pressure and anti inflammatory activity However, this mushroom may provoke allergic reactions and a peculiar dermatosis, known as shiitake dermatitis We reported a case of shiitake dermatitis in 54 year old Caucasian woman, who developed acute lesions 2 days after eating a raw shiitake mushroom for the first time