Magnetic particles (beads) have been studied because of their many promising biomedical applications. Those are suitable to be used in biosensor applications, since their magnetic properties allow relatively easy (and remote) detection, large surface to volume ratio and mobility, but one of the most important advantages is that the magnetic background of even complex biological fluids is very low. Here we propose a GMR (TMR) biosensor [1] where at least the ground state of the “free layer” of the sensor is a magnetic vortex configuration of any chirality (clockwise or counter-clockwise) and any polarity (positive or negative) [2]. The magnetization of the polarized layer can be either in non-uniform (for example vortex configuration) or in uniform configuration. The two ferromagnets can be separated by a normal metal (GMR-vortex biosensor) or by an insulator (TMR-vortex biosensor).