Chlorhexidine (CHX) is a bis-bis-guanide widely used to treat skin and mucosa infections, efficient against a wide range of microbial species. The aim of this work was to design and evaluate gels containing CHX associated to mucoadhesive and swelling agents, such as CMC, HPMC, HPC and Poloxamer, to control both the residence time in the oral cavity and the release rate of the drug. Three tests were carried out to evaluate the controlled release of CHX from the gels; also the interaction polymer-mucin by means of viscosimetric measurements was tested. The same tests were also applied to a commercial formulation, Corsodyl gel® for comparison.