The paper is about the use of Modeling & Simulation together with Artificial Intelligence, Intelligent Agents and Data Analytics tools and techniques for supporting Strategic Decisions. It focuses on innovative architectures, models and solutions while creating a working experience on these innovative frameworks for a wide spectrum of applications: from Business to Industry, from Defense to Homeland Security, from Oil & Gas to Public Services. Our contribution includes methodologies, techniques, frameworks, software solutions and procedural approaches as well as projects, proof of concepts, validation & verification and capability demonstrations.