LL-Z1271alpha: an interleukin-1beta production inhibitor.
Copyright policy )LL-Z1271alpha: an interleukin-1beta production inhibitor.
LL-Z1271alpha, a fungal metabolite, dose-dependently inhibited interleukin-1beta (IL-1beta) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271alpha to LPS-challenged mice caused significant lowering in the IL-1beta levels in peritoneal cavity. Data presented suggest that LL-Z1271alpha inhibits IL-1beta production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1beta converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect.
- Pfizer (Japan) Japan
Lipopolysaccharides, Mice, Adenosine Triphosphate, Dose-Response Relationship, Drug, Terpenes, Animals, Humans, Caspase Inhibitors, Cells, Cultured, Interleukin-1
Lipopolysaccharides, Mice, Adenosine Triphosphate, Dose-Response Relationship, Drug, Terpenes, Animals, Humans, Caspase Inhibitors, Cells, Cultured, Interleukin-1
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