Synaptosomal-associated protein (SNAP-25) polymorphisms and response to olanzapine in schizophrenia patients
Synaptosomal-associated protein (SNAP-25) polymorphisms and response to olanzapine in schizophrenia patients
Introduction: Genetic factors may influence response to antipsychotic treatment in patients with schizophrenia. The synaptosomal-associated protein of 25 kDa (SNAP-25) gene may be an interesting candidate gene regarding clinical outcome with antipsychotics. SNAP-25 is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters (1). Muller et al. reported that Mu1I T/G, Tail T/C polymorphisms in the SNAP-25 gene were associated with both antipsychotic drug response and drug induced weight gain (3). We aimed to evaluate the association of SNAP-25 (Mn1I T/G and Ddell T/C) polymorphisms with response to olanzapine in our study.
- Atatürk University Turkey
- Pamukkale University Turkey
- Gazi University Turkey
protein polymorphism, genotype, olanzapine, disease association, treatment response, genetic analysis, major clinical study, schizophrenia, Genetic, synaptosomal associated protein 25, Olanzapine, SNAP-25, human, conference paper, diagnostic and statistical manual of mental disorders, rating scale
protein polymorphism, genotype, olanzapine, disease association, treatment response, genetic analysis, major clinical study, schizophrenia, Genetic, synaptosomal associated protein 25, Olanzapine, SNAP-25, human, conference paper, diagnostic and statistical manual of mental disorders, rating scale
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