Scientific and technological development in morphological disciplines has created an creates unheard of possibilities for scientific research and practical examination of morphological changes and in its consequences has contributed also in a substantial way to a change in fundamental views on the subcellular and supramolecular structural level of the organization of living matter. Despite this pathology is faced with difficulties and has at present many unresolved theoretical and practical problems. Pathology has expanded so much that is differentiation as regard contents and methods is inevitable to preserve its integrity and to promote its integrity with other disciplines in particular biochemistry of tissue changes. The basic types of activity of pathology will remain also in future (histological) biopsy, cytodiagnostics and necropsy whereby it is necessary to use to an increasing extent new methods contributed by the scientific and technological revolution. It must not be forgotten that pathology is not only a specialized but also scientific discipline and important source for all doctors in their therapeutic and preventive and scientific activities.