The purpose of this study is to investigate prospective science teachers’ computer related self-efficacy perceptions in terms of gender, general academic achievement and grade level. This is a descriptive field survey. The study group of the research comprised of totally 226 students. “Computer-related Self Efficacy Perception Scale” and “Demographic Information Form” were used as data collection tools. In the analysis of the data, descriptive statistics, independent t-test, one-way ANOVA and Pearson correlation coefficient were used. At the end of the study, computer-related self-efficacy perception scores of teachers were determined as in medium level. While it was found out that computer-related self-efficacy perception scores of prospective teachers differed significantly according to gender and grade level, it was determined that they didn’t differ significantly according to general academic achievement. It was revealed that there were high and medium-level positive relationships between prospective teachers’ computer-related self efficacy perception scores and gender, grade level and academic achievement