This research aimed to examine the relationship between high school students' well-being levels and career anxiety levels and career indecision. Research data were collected from 663 students (398 girls, 265 boys) studying in Anatolian high schools and vocational high schools. Career Decision Inventory, Warwick-Edinburgh Mental Well-being Scale, and Career Anxiety Scale were used to collect data. The Hierarchical Regression Analysis was used in the data analysis. The research results show a significant negative relationship between career indecision and well-being and a significant positive relationship between career indecision and career anxiety. According to the hierarchical regression analysis results, well-being and career anxiety are significant predictors of career indecision. Variables of well-being, and career anxiety (anxiety on family effect, anxiety on vocation choice) explain 43% of total variance for career indecision. These results are discussed within the framework of the related literature.