Ovulation and the ovarian cycle occur through these two physiological activities of the ovary, periodic release of oocytes and steroid hormone production. And it is the gonadotropic hormones of the pituitary gland that control the repetitive process of follicle maturation, ovulation, corpus luteum formation, and regression in the ovarian cycle. Failure of ovulation (amenorrhea or oligomenorrhoea) can be identified in 18 to 25% of couples with infertility. The purpose of ovulation induction is to achieve monofollicular development that will improve the outcome of pregnancy by obtaining normo/mono-ovulatory cycles in these women. In this chapter, we aim to review different regiments used for ovulation induction and to provide the best approach in the management of women with anovulation as the cause of infertility. © 2023 Nova Science Publishers, Inc. All rights reserved.