For all diabetic patients in which the blood glucose is unstable, self-monitoring of blood glucose (SMBG) is effective. Especially, the patient who insulin supplies are necessary is indispensable SMBG in spite of tyep 1 and/or type 2 diabetes mellitus. SMBG measuring devices of looked forward nothing noninvasive type entered the practical stage. For example, the patient who requires the frequent measurement can be applied to alarms of the hypoglycemia unawareness, etc. from present performance, because blood glucose monitoring in the any time possible, though changing in taking in SMBG measuring device of the conventional invasive type, is not possible. And, it is possible to utilize in health care and protective measurement of the lifestyle related disease, etc., because the daily observation of the blood glucose is carried out in the long term. The function of data assist center, etc. is expected these this data for processing through the internet, etc. and follow of the result.