
The author reviews studies of live cold-adapted reassortant influenza vaccines developed in Russia and USA. These vaccines are safe and weakly reactogenic for all age groups. The vaccines (two immunizations) are highly effective in children of preschool and school age and far less effective in adults. For elderly subjects simultaneous vaccination with live and inactivated vaccines is recommended. The probability of influenza prevention by a single injection of cold-adapted vaccines is to be further investigated. Modern data indicate that cold-adapted reassortant influenza vaccines can be used for influenza prevention only in children of preschool and school age.
Cold Temperature, Influenza Vaccines, Adaptation, Biological, Humans, Reassortant Viruses, United States, Russia
Cold Temperature, Influenza Vaccines, Adaptation, Biological, Humans, Reassortant Viruses, United States, Russia
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 5 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
