[Mechanisms of long-term synaptic depression in the hippocampus].
Copyright policy )[Mechanisms of long-term synaptic depression in the hippocampus].
Long-term depression (LTD) was studied in hippocampal slices obtained from neonatal rats at the synapses between CA3 and CA1 pyramidal neurons. The induction of the LTD required pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated Ca2+ channels with activation of metabotropic glutamate receptors. The expression of this form of LTD is at least partly presynaptic, suggesting the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus applications of arachidonic acid simulate LTD whereas blockade of arachiidonic acid release inhibits LTD.
- Harvard University United States
Arachidonic Acid, Patch-Clamp Techniques, In Vitro Techniques, Receptors, Metabotropic Glutamate, Hippocampus, Synaptic Transmission, Rats, Rats, Sprague-Dawley, Animals, Newborn, Excitatory Amino Acid Agonists, Animals, Calcium
Arachidonic Acid, Patch-Clamp Techniques, In Vitro Techniques, Receptors, Metabotropic Glutamate, Hippocampus, Synaptic Transmission, Rats, Rats, Sprague-Dawley, Animals, Newborn, Excitatory Amino Acid Agonists, Animals, Calcium
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