4H-Pyran-4-one derivatives:
4H-Pyran-4-one derivatives:
A series of 3-hydroxy-6-methyl-2-((4-substitutedpiperazin-1-yl)methyl)-4H-pyran-4-on e structured compounds were synthesized by reacting 5-hydroxy-2-methyl-4H-pyran-4-one with suitable piperazine derivatives using Mannich reaction conditions. Antibacterial activities of the compounds for E. coli, S. paratyphi, S. flexneri, E. gergoviae, and M. smegmatis were assessed in vitro by using broth dilution for determination of the minimum inhibitory concentration (MIC). In addition, their inhibitory effects over DNA gyrase enzyme were evaluated using a DNA gyrase supercoiling assay. Among the synthesized compounds
- Acıbadem University Turkey
Antimycobacterial activity, DNA gyrase activity, hydroxy-4H-pyran-4-one
Antimycobacterial activity, DNA gyrase activity, hydroxy-4H-pyran-4-one
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