Among the types of muscles present in the body is skeletal muscle, which is the one that allows the development of physical activity thanks to the contractile activity of its muscle cells. It is known that physical exercise involves the release of plasma, by the skeletal muscle, of molecules called myokines as a result of muscle contraction. These myokines seem to be at the base of the beneficial effect of physical exercise on health. For this reason, this article reviews the characteristics and properties of the most important myokines and how they can contribute to a healthier aging.